Antifungal solution and wipe

ABSTRACT

A wipe has a substrate, a treatment solution impregnated into the substrate, the treatment solution including an antifungal agent, an antifungal agent solvent, and a carrier fluid, wherein the treatment solution is essentially free of alcohol. A treatment solution, has an antifungal agent, an antifungal agent solvent, and a carrier fluid, wherein the treatment solution has an alcohol content of 6 wt % or below of the total solution.

RELATED APPLICATIONS

This application is a divisional of U.S. patent application Ser. No.16/299,454, filed Mar. 12, 2019, which is a continuation of and claimspriority to U.S. Provisional Patent Application Nos. 62/643,627, filedMar. 15, 2018; 62/715,631, filed Aug. 7, 2018; and 62/782,550, filedDec. 20, 2018, which are incorporated herein by reference in theirentirety.

TECHNICAL FIELD

This disclosure relates to an essentially alcohol-free, antifungaltreatment solution for skin care, which may be in the form of a wipe,aerosol spray, spray, liquid, lotion or cream, as examples withoutlimitation.

BACKGROUND

Over-the-counter antifungal treatments for the treatment and/orprevention of athlete's foot and other foot funguses generally take theform of creams or sprays. For sprays the antifungal ingredient usuallyconsists of terbinafine hydrochloride, miconazole nitrate, ortolnaftate. The sprays all include alcohol used as a solvent to keep theactive ingredients in solution so they can propel out of the container.The propellant may consist of isobutane, n-butane, and propane. Dimethylether (DME) may also be a propellant. The alcohol is also added to givethe skin a “cooling” sensation and aid in skin permeation when applied.None of these materials are good for the skin.

The container often consists of an aerosol can. Alternatives to aerosolcans have several advantages. For example all the aerosol metal cansused to apply athlete's foot sprays are non-recyclable metal aerosolspray cans. These non-recyclable cans are an inefficient delivery systemand not good for the environment.

Alternative forms of over-the-counter antifungal treatment exist increams and powders. Foot creams often have the same ingredients as thesprays, minus the propellants and almost universally include alcohol.Another item to note is that many available over-the-counter foot creamsuse either terbinafine hydrochloride, tolnaftate, butenafinehydrochloride, or clotrimazole as the antifungal ingredient, referred tohere as the active ingredient. Powders seem to be more directed toprevention rather than curing foot fungal infections. Many of thepowders have no over the counter antifungal active ingredients at all.Some powders contain menthol, which is not a proven FDA antifungal butthe powders list as their active ingredient.

Another issue that arises from the application of the active ingredientsin the form of either sprays or creams. Typically, the instructions arefirst to clean, then to apply to the affected area such as in betweenthe toes, or to apply to the toes to prevent infection. For powders, theinstructions typically involve sprinkling the toes with the powder, orputting it in shoes or socks for prevention of athlete's foot. Thisdelivery system does not make for efficient applications of the activeingredients. A better delivery system and more efficacious formula forantifungal treatments for the feet would be desirable.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows one embodiment of an antifungal wipe substrate.

FIG. 2 shows an embodiment of a pop-up package for antifungal wipes.

FIG. 3 shows an embodiment of a flat package for antifungal wipes.

FIG. 4 shows an embodiment of individual packages for antifungal wipes.

DETAILED DESCRIPTION OF THE EMBODIMENTS

As used here, the term “treatment solution” means a solution comprisedat least of an antifungal agent and a carrier fluid, which may alsoinclude an antifungal agent solvent. As used here, the term “antifungalagent” means any drugs, identified at least below, used to at leasttreat, and may treat and prevent, fungal infections, including athlete'sfoot, tinea pedis, ringworm, tinea capitis, and jock itch, tinea cruris.One should note that while much of the discussion focuses on athlete'sfoot, the application of the embodiments here is not limited to thatparticular fungal infection and should not be construed as such alimitation.

The embodiments here generally comprise an antifungal and soothing,healing solution that cleans, conditions, revitalizes and protects. Asmentioned above, the treatment solution may contain several components,or it may consist only of a carrier fluid that carries the amount ofantifungal agent needed. The US Food and Drug Administration requiresthat the antifungal ingredient be present in specific amounts. Thefollowing are drugs that have received the US FDA's approval asantifungals in its Final Monograph: tolnaftate 1%, clioquinol 3%;haloprogin 1%; miconazole nitrate 2%; povidone iodine 10%; undecylenicacid and its salts of calcium, copper and zinc, for a total undecylenateconcentration of 10-25%; and clotrimazole 1%.

It is important to note, all the drugs listed are only approved for thetreatment of athlete's foot and the relief of symptoms due to athlete'sfoot. However, only tolnaftate, a naphthyl thiocarbamate, is alsoapproved for the prevention of athlete's foot. The above drugs containedwithin the FDA's Final Monograph are considered Generally Recognized AsSafe and Effective (GRASE) for the treatment of athlete's foot. Inaddition, terbinafine hydrochloride received approval by the FDA as atreatment only for athlete's foot within the individually filed New DrugApplication.

Other drugs that are used for the treatment of athlete's foot notcontained within the Final Monograph by the FDA are: ketoconazole, animidazole,(1-[4-(4-{[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-1-piperazinyl]ethanone);sulconazole, an imidazole(1-{2-[(4-Chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole);sertaconazole, an imidazole(1-{2-[(7-Chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole);betamethasone((11β,16β)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione)+clotrimazole,an imidazole (1-[(2-Chlorophenyl)(diphenyl)methyl]-1H-imidazole);ciclopirox (6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone); econazole(1-{2-[(4-Chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole);naftifin ((2E)-N-Methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine);oxiconazole((1Z)-N-[(2,4-Dichlorobenzyl)oxy]-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanimine);butenafine, a Trimethylamine,(N-Methyl-1-[4-(2-methyl-2-propanyl)phenyl]-N-(1-naphthylmethyl)methanamine);undecylenic acid+cholorozylenol (para-chloro-meta-xylenol). Any of theseingredients could be used in place of the tolnaftate, but they are onlyapproved for the treatment and not the prevention of athlete's foot.

As used herein “an effective amount” for the antifungal agent means theamounts indicated in the FDA's Final Monograph for treatment and/orprevention of tinea infections, such as athlete's foot, jock itch,ringworm and related skin conditions. For antifungal agent not listed onFDA's Final Monograph, an amount of at least USP 1%-12% by weight of thesolution should be utilized in the formulation.

The present formulation of the treatment solution contains an antifungalagent in an effective amount. The selected antifungal agent amounts mayvary and should be within the amounts indicated by the FDA's FinalMonograph or as defined herein. The antifungal agent can be for thetreatment of tinea infections, it can be for the prevention of tineainfections or it can be for both treatment and prevention of tineainfections. The antifungal agent is selected from a naphthylthiocarbamate active such as tolnaftate USP 1%, hydroxyquinolines suchas clioquinol USP 3%; haloprogin(1,2,4-trichloro-5-(3-iodoprop-2-ynoxy)benzene) USP 1%; miconazolenitrate(1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid) USP 2%; povidone iodine (1-ethenylpyrrolidin-2-one; iodine)USP 10%; undecylenic acid and its salts USP 10-25%; and imidazoleantifungal agents include sulconazole nitrate, econazole nitrate,miconazole nitrate and clotrimazole(1-[(2-chlorophenyl)-diphenylmethyl]imidazole) USP 1%.

The treatment solution contains a carrier fluid. The carrier fluid isessentially free of alcohols. As used herein, “alcohols” means SDalcohol, denatured alcohol, isopropyl alcohol, ethanol and mixturesthereof. As used herein “essentially free of” means that alcohols arenot intentionally included in the present formulation, such as beingpresent less than 1 wt % of the treatment solution. Alcohols may becarrier materials for other materials included in the treatmentsolution, or act as a preservative, but alcohols are not utilized forsolubilizing the antifungal agent.

Suitable carrier fluids include water, glycerol, ethylene glycol, lowmolecular weight polyethylene glycol, the low molecular weightpolyethylene glycol comprising an average molecular weight less than1500, such as between 300 and 1500. In one embodiment, the carrier fluidcomprises water. In one embodiment, the carrier fluid comprises waterand glycerol. In one embodiment, the carrier fluid comprises water andethylene glycol. In one embodiment, the carrier fluid comprises waterand low molecular weight polyethylene glycol.

The treatment solution may also contain an antifungal agent solvent. Asolvent is generally defined as a material that can dissolve othersubstances. In the treatment solution, the solvent keeps the othercomponents of the solution in solution form, allowing the treatmentsolution to be wiped on the skin. Solvents may have a concentration of0.01% to 40%, either individually or as a class. The class of materialsthat includes dioxolane is referred to generally as heterocyclic acetalsolvent. Other ranges include 0.5% to 10%, 1% to 3%.

The antifungal agent solvent solubilizes the antifungal agent such thatit is soluble in a carrier fluid that is essentially free of alcohols.The antifungal agent solvent is not intended to form an emulsion withthe carrier fluid, but rather to be miscible with the carrier fluid andis stable. Being miscible means that the first fluid and the secondfluid do not separate from each other, and being stable means that theseparation does not occur even over time. It is further desired that theantifungal agent solvent is volatile and evaporates quickly after it isapplied, it dries quickly, is non-greasy and non-oily.

A suitable antifungal agent solvent comprises a logKow between about −1and about 1; or from about −1 to about 0. Kow (or log Kow) is theoctanol/water partition coefficient and represents the ratio of achemical's concentration in the octanol phase to its concentration inthe aqueous phase of a two-phase octanol/water system. A negative orsmall Kow indicates an affinity for water miscibility or hydrophilicity.A log Kow between −1 and 1 means that the measures Kow is between 10⁻¹and 10, so the log Kow is −1 to 1.

Kow=Concentration in octanol phase/Concentration in aqueous phase.

A suitable antifungal agent solvent with a boiling point at 25° C.,roughly room temperature, has a higher vapor pressure and would beconsidered to be volatile. Stated another way, a suitable antifungalagent solvent comprises a boiling point below 250° C., 200° C., below180° C., 150° C., or below 100° C.

One embodiment of the treatment solution contains between about 0.01 wt% and about 10 wt % by weight of the treatment solution, such as betweenabout 0.01 wt % and about 5 wt %, such as between about 0.5 wt % andabout 3 wt %, such as 0.5 wt %, 1.0 wt %, 1.5 wt %, 2 wt %, 2.5 wt %,3.0 wt %. The present formulation contains a weight ratio of theantifungal agent to the antifungal agent solvent from 1:6 to 6:1inclusive, such as 1:1, 1:2, 1:3, 1:4, 1:5, 1:6 6:1, 5:1, 4:1, 3:1, 2:1,including any other amounts in the range.

Antifungal Solvent CAS No. Structure Boiling pt. ° C. LogKow1,3-dioxolan; aka 1,4-dioxolane 646-06-0

 76.35 −0.37 4-Methyl-1,3- dioxolane 1072-47-5

 86 0.37920 2-methyl-1,3- dioxolane 497-26-7

172-173 (2-Methyl-1,3- dioxolan-4- yl)methanol 3773-93-1

187.0 ± 0.0° C. 1,3-Dioxepane 505-67-7

119 0.77090 1,3-Dioxolane-4- methanol 5464-28-8

192-193° C. 5-Hydroxy-1,3- dioxane 4740-78-7

192-193° C. −1.082 Glycrol formal mixture (60:40) of 1,3-Dioxolane-4-methano1:5- Hydroxy-1,3- dioxane 68442-91-1 192-193° C. 1,4-dioxane123-91-1

101.1 1,3-dioxolane-2- one 96-49-1

248

A suitable antifungal agent solvent consists of an aprotic solvent witha log Kow between about −1 and about 1. A log Kow indicates that thesolvent is soluble and miscible in water.

A suitable antifungal agent solvent may be selected from a heterocyclicacetyl solvent. A suitable antifungal agent solvent may be selected from1,3-dioxolane, 4-Methyl-1,3-dioxolane, 2-methyl-1,3-dioxolane,(2-Methyl-1,3-dioxolan-4-yl) methanol, 1,3-Dioxepane,1,3-Dioxolane-4-methanol, 5-Hydroxy-1,3-dioxane, Glycrol formal mixture(60:40) of 1,3-Dioxolane-4-methano1:5-Hydroxy-1,3-dioxane, 1,4-dioxane,1,3-dioxolane-2-one, and mixtures thereof. Without being bound by atheory, the antifungal agent complexes with the antifungal solvent toform a water-soluble antifungal agent complex; the antifungal agentcomplex is miscible with the carrier. As such, an emulsion is not formedwithin the carrier fluid. In one embodiment, 1,3-dioxolane is theantifungal agent solvent. In one embodiment, 1,3-Dioxolane-4-methanol isthe antifungal agent solvent. In one embodiment, 5-Hydroxy-1,3-dioxaneis the antifungal agent solvent. These variations of dioxolane will bereferred to generally as dioxolane in the current discussion.

As mentioned above, the treatment solution may contain severalcomponents, or it may be a carrier fluid having only the amount ofantifungal needed. The US Food and Drug Administration requires that theantifungal ingredient have a set percentage of the solution by weight(wt %). In one embodiment, tolnaftate comprises 1 wt % of the solution,with a carrier fluid, such as water, or a mixture of water and glycerin(or other inactive ingredients) making up the remaining 99 wt %.

The treatment solution may also contain inactive ingredients, which willbe discussed by each class of component, with given examples and rangesof concentration for each, with the understanding that the componentsthemselves are optional beyond the active ingredient, as are anycombination of ingredients. The active ingredient is the antifungalagent

The term ‘inactive ingredient’ means an ingredient that is notantifungal, even though the ingredient may have other active properties,like conditioning, moisturizing, etc. The treatment solution may alsocontain inactive materials. The classes of materials used as inactiveingredients in the solution include emollients, surfactants, textureenhancers or texturizers, moisturizers, solvents, anti-inflammatoryagents, deodorants, anti-bacterial, and curative ingredients. Curativeingredients improve texture, nourish the skin, reduce infections,increase circulation, etc.

For example, eucalyptus, peppermint and tea tree oil may be used asantibacterial ingredients but are not approved by the FDA as anantifungal for athlete's foot. The class of materials that includetolnaftate are generally referred to as naphthyl thionocarbamateactives.

As mentioned above, other active ingredients/antifungal agents could beused to treat athlete's foot, such as: clioquinol 3%; haloprogin 1%;miconazole nitrate 2%; povidone iodine 10%; undecylenic acid and itssalts of calcium, copper and zinc, for a total undecylenateconcentration of 10-25%; and clotrimazole. Other drugs previouslymentioned, while not contained in the FDA's, may also be used as theantifungal agent.

It is important to note, all the drugs listed above are only approved bythe FDA for the treatment of athlete's foot and the relief of symptomsdue to athlete's foot. However, only tolnaftate is also approved for theprevention of athlete's foot.

Some embodiments of the treatment solution may include emollients.Emollients are generally defined as a preparation that softens orsoothes the skin. These may moisturize to treat or prevent dry, rough,scaly, itchy skin and minor skin irritations. Emollient ingredients inthe treatment solution may include glycerin, gossypium herbaceum (cottonseed oil), polyglyceryl-4 laurate, dilaurly citrate, ethylexyl stearate,and caprylyl glycol. These are just representative materials ofemollients. These ingredients may have a range of concentration from0.01% to 40%, either alone or as a class of ingredients. The emollientor combination of emollient may comprise from about 0.01 wt % to about 3wt % by weight of the treatment solution. Suitable emollients may beselected from glycerin, gossypium herbaceum (cotton seed oil),polyglyceryl-4 laurate, dilaurly citrate, ethylexyl stearate, andcaprylyl glycol (a combination of gossypium herbaceum(cotton seed oil),polyglyceryl-4 laurate, dilaurly citrate, ethylexyl stearate is soldunder the tradename of TEGO WIPE LUX®). These ingredients may have arange of concentration from 0.01% to 40%, either alone or as a class ofingredients.

In addition to emollients, there may be moisturizers. Moisturizers mayinclude glycerin, which can also act as an emollient, and tocopherolacetate, which is a form of vitamin E. Other forms of vitamin E may alsobe used. Vitamin E is a natural skin conditioning agent and antioxidant.Moisturizers may have a concentration of 0.01% to 40%, eitherindividually or as a class. The present formulation of the treatmentsolution may optionally contain vitamin E, vitamin E esters, and saltsthereof, such as tocopheryl acetate, tocopheryl succinate, tocopherylnicotinate, tocopheryl linolate, alpha-tocopheryl phosphates. Suitablelevels of vitamin E, vitamin E esters and salts thereof is from about0.001 to about 0.5 wt % by weight of the treatment solution. In oneembodiment tocopheryl acetate is present at about 0.01 wt %.

These and other embodiments may include another class of materialsconsisting of surfactants. A surfactant is a material that alters thesurface energy of a substance, most commonly it tends to reduce thesurface tension of a liquid in which it dissolved. In cleaningapplications, it tends to reduce the adherence of particles to surfacesto allow them to be lifted away. Examples include sodium lauroylsarcosinate, a foaming and cleansing agent made form coconut oil.Another example consists of sodium laurylamphoacetate, another foamingand cleansing agent that also conditions the skin. Yet another exampleconsists of sorbitan laurate, it helps water mix with dirt and oil toallow the water to carry them away. Surfactants may have a concentrationof 0.01% to 40%, either individually or as a class.

The use of surfactants is not intended to create an emulsion of theantifungal agent in the carrier solution, as discussed above. Rather,the amounts of surfactant should be such that a foaming or cleaning ofsoils from the skin surface contacting by the treatment is accomplished.In one embodiment, surfactants are selected from sodium lauroylsarcosiate and sodium laurylamphoacette, and are present between about0.01% to about 10 wt % by weight of the treatment solution, such as fromabout 0.1 wt % to about 1.5 wt % individually and together less than 3wt % by weight of the treatment solution.

Embodiments of the treatment solution may optionally contain athickening agent between about 0.01 wt % to about 10 wt % by weight ofthe treatment solution. The thickening agent may be present from about0.01 wt % to about 3 wt % by weight of the treatment solution. Asuitable thickening agent may be selected from ammoniumacryloyldimethyltaurate/Vp copolymer, sodium polyacrylate, a mixture ofcaprylic/capric triglyceride and ammonium acryloyldimethyltaurate/VPcopolymer, xanthan gum, karaya gum, alginates, sclerotium gum,galactoarabinan, diutan gum, guar gum, locust bean gum, and gellan gum;fumed silicas and treated silicas; silicates; starch and its hydrophilicderivatives; and mixtures thereof. In one embodiment the inactiveingredients include ammonium acryloyldimethyltaurate/Vp copolymer. Itcan act as a texture enhancer, it thickens the foam and makes it smoothagainst the skin. Texture enhancers may have a concentration of 0.01% to40%, either individually or as a class.

Other inactive ingredients may include alpha hydroxy acid and/or otherexfoliants, vitamin C, vitamin B, vitamin K, and various essential oils,such as, without limitation, tea tree oil, coconut oil, lanolin, citricacid, aloe vera, lavender, saline, mineral oil, argan oil, avocado oil,jojoba oil, peppermint oil, eucalyptus oil, etc.

One or more essential oil(s) may be present from about 0.001 wt % to 1wt % of the treatment solution, such as from about 0.01 wt % to about0.5 wt % of the treatment solution. Suitable essential oils may beselected to provide a conditioning or skin benefit. Suitable essentialoils may be selected from chamomile oil, geranium oil, peppermint oil,eucalyptus oil, juniper oil, sandalwood oil, rose oil, lavender oil, andmixtures thereof.

Two essential oils that have beneficial and therapeutic effects areeucalyptus and peppermint. Eucalyptus has anti-inflammatory,deodorizing, antiseptic, antibacterial and stimulating properties thatmay make the skin on the user's foot or feet feel better. Similarly,peppermint has nourishing, texture-improving, infection-reducing,circulation-increasing properties and blends well with eucalyptus. Whenthese two inactive ingredients are initially applied to the surface ofthe skin, the skin feels cool and fresh without the negative sideeffects of alcohol. These ingredients may have a concentration in therange from 0.01 wt % to 5% each, such as 0.2 wt %.

In one embodiment, tolnaftate comprises 1 wt % of the solution,peppermint comprises 0.25 wt %, eucalyptus comprises 0.25 wt % relativeto the solution, with any combination of the other inactive ingredientsmaking up the 98.5 wt %. Other embodiments have peppermint andeucalyptus at 0.1 wt % each. Still other embodiments have peppermint andeucalyptus at 1.0 wt % each.

In one embodiment, tolnaftate comprises 1 wt % of the solution,peppermint has a concentration range of 0.01 wt % to 5 wt % relative tothe solution, and eucalyptus has a concentration in the range of 0.01 wt% to 5 wt % relative to the solution, with any combination of the otherinactive ingredients making up a range of 89 wt %-98.98 wt % relative tothe solution.

One should note that the oils used here do not interact with theantifungal agent or antifungal agent solvent. The antifungal agent, suchas tolnaftate, does not dissolve in, nor does it become solubilized inthe oils. One current solution consists of dissolving tolnaftate intojojoba oil, and does not use water or glycol. The antifungal agent inthe embodiments here are solubilized by the antifungal agent solvent.

One ingredient that will not be included in the treatment solution isalcohol. Alcohol is often used in skincare or makeup products. It givesthe products a quick-drying finish, immediately degreases the skin, andfeels weightless on the skin, so it often appeals to users, especiallythose with oily skin. Typically, the alcohol used is listed as SDalcohol, denatured alcohol, isopropyl alcohol, or ethanol. Denaturedalcohol is a drying type of alcohol that aggravates and weakens theskin. However, the use of alcohol will aggravate and be cruel to theskin. Consequences include dryness, erosion of the skin surface, andstrain on skin replenishment, renewal, and rejuvenation. The FDAdiscourages the use of alcohol for bodily cleansing. Ethanol alsodestroys skin cells, called apoptosis. Alcohol, when applied to any skinthat is broken or cut, will cause burning pain in conditions such asathlete's foot. For feet, which often have blisters and sore spots, theuse of alcohol seems ill-advised, although the anti-bacterial propertiesare well-know.

Using dioxolane as a solvent, combined with a surfactant and water,allows the active ingredient to be completely solubilized and stable,meaning the active ingredient is completely in solution form and remainsthat way, without the use of alcohol. “Without the use of alcohol” asused here is equivalent to “alcohol-free” or “essentially free ofalcohol” and means that the solution contains between zero (0 wt %) and1 wt % alcohol. This means that alcohol is not intentionally added tothe solution.

The University of Toronto's departments of Clinical Pharmacology,Dermatology and Medicine conducted a dermatological study thatillustrated the correlation of ethanol exposure and skin celldestruction. Application of 3% ethanol to skin cells over the course oftwo days resulted in an increase of cell death by 26%. Most antisepticwipes contain 60% alcohol, more than 20 times the amount tested in thestudy. The study also revealed that alcohol terminates the substances inskin cells that reduce inflammation and defend against free radicals.

According to the Journal of Occupational Medicine and Toxicology,Alcohol (Ethanol) is a topical penetration enhancer. Ethanol enters theskin and removes significant quantities of the lipid barrier materialfrom the stratum comeum. The barrier function of the skin relies almostentirely on the stratum comeum. By extracting the lipids, the skinbarrier function weakens and may render the membrane more permeable,

The stratum comeum acts as the first line of defense against theexternal environment. It is a compact layer of cells and lipids that hastwo critical functions: it protects our bodies from bacteria, UV damageand other assaults; and prevents natural moisture from escaping, to keepskin hydrated. Most, if not all, currently available over-the-countertreatment products for athlete's foot use alcohol.

However, if one were to add alcohol, the mixture would remain ‘lowalcohol’ defined here as having 6 wt % or less of the final solution.The solution could contain one of 5 wt %, 4 wt %, 3 wt %, 2 wt %, or 1wt %. That percentage would result from an arithmetic sum of theindividual levels of all alcohols. In one embodiment, the alcohols couldbe selected from the group consisting of SD ethanol, denatured ethanol,and isopropyl alcohol, but no limitation to the types of alcohols isintended. Other ranges of low-alcohol solutions may have 5% or less, or2% or less.

Some embodiments relate to an antifungal and conditioning wipe articlecomprising a substrate treatment solution having an antifungal agent, anantifungal agent solvent, and a carrier fluid. The solution may bedelivered through a wipe to a person's feet, or other body partsuffering from a fungal infection, or take the form of a cream, lotion,or fluid. The treatment solution will treat and prevent such fungalconditions as athlete's foot, and provides healing and soothingproperties. It eliminates odors, and has both a fresh scent and leaves auser's body parts smelling fresh. As discussed above, the treatmentsolution should be essentially free of alcohols.

As used here, the terms “substrate” and “wipe” refer to a piece orcomplete item of material that can accept the treatment solution. Thewipe, or substrate, could take one of many forms, including creped orun-creped tissue, coform products, hydroentangled (spun lace) webs,air-laid mats, fluff pulp, nonwoven webs, woven webs, and composites ofany of the above.

FIG. 1 shows an embodiment of a wipe or substrate 10. The surface of thewipe or substrate may have a quilted surface 12. As discussed below, thewipe may have texture in the form of bumps, such as those shown in theregion 14. The texture may cover the entire wipe or just a portion ofit. The texture may contribute to the exfoliation of the user's feet,not just treating the skin by applying the solution, but also byloosening and then removing infected dead skin cells.

In one embodiment, the substrate may take the form of lyocell. A common,commercially available form of lyocell is sold under the name Tencel®.Lyocell typically consists of wood-based cellulose fibers made from woodpulp. It is a form of rayon, not to be confused with viscose rayon.

The US Federal Trade Commission defines lyocell as a fiber “composed ofcellulose precipitated from an organic solution in which no substitutionof the hydroxyl groups takes place and no chemical intermediates arefound.” It is classified as a sub-category of rayon. lyocell can beblended with many different fibers, including silk, cotton, rayon,polyester, linen, nylon, and wool. One blend of lyocell, under thetrademark Tencel+Plus™ is lyocell from eucalyptus. This fits well withthe treatment solution, as some embodiments of the treatment solutionuses eucalyptus.

Regardless of the material used, the substrate should resist dissolvingin the treatment solution when stored as an antifungal and conditioningwipe article. Some of this may be determined by the basis weight of thewipe article. The basis weight is the weight per unit area of thesubstrate or wipe, and is often measured by weighing a sample of knowsize and determining the grams of weight per square meter (m²). Thesubstrate sheet of use in some embodiments may have a basis weightranging from about 25 g/m² to about 75 g/m², such as a basis weightranging from about 40 g/m² to about 60 g/m². In one embodiment, thesubstrate has a weight of 50 grams per square meter, but any weight thatis sufficient to avoid rolling up during use will work. Otherpossibilities include ranges of 25 to 75 grams per square meter, or 40to 60 grams per square meter. One embodiment has a weight of 50 gramsper square meter.

The wipes may be stored in a container, such as a pop-up container shownin FIG. 2, similar to those used for facial tissue or baby wipes, in aflat pack such as those shown in FIG. 3, where the user has to open andextract the wipe, or in individual packets. As shown in FIG. 2, thecontainer 20 may consist of a lid 22 and a body 28. A stack of wipes,not visible, are accessed through an opening 24, through which the wipecan be pulled. A flat pack 30, such as that shown in FIG. 3, typicallyhas a body 38. The wipes reside inside the pack. A user would pull theflap 32 away from the body 38, which may be held close by some sort of aclosure 36. The flap 32 covers the opening 34. Closure 36 may comprisesome sort of adhesive or sticky patch, electrostatic cling, as examplesof closures that can keep the flap tight enough to the body to avoid thesolution leaking or evaporating, which would in turn cause the wipes todry. Alternative packages may include individually wrapped singlepackets as shown in FIG. 4. The individual packages 40 have a sealedbody 42 and may have a notch 42 to allow a user a convenient way to openthe package.

These are just some examples and are in no way intended to limit thescope of any embodiments to a particular container. The treatmentsolution is applied to the wipe and then packaged and stored, soresisting dissolving allows for longer storage.

The wipe is used to deliver the solution to the affected surface or tojust be applied to the foot for preventative, healing, or soothingreasons. The user will be wiping or scrubbing the surfaces of the feet,including the top, bottom, sides and on top of and between the toes, orother affected body parts. The wipe should have sufficient structuralintegrity that it does not roll up, rip, or otherwise fall apart whenthe user wipes the foot with them.

The substrate may be smooth, without texture, and have a thickness inthe range of 0.40 millimeter (mm), or it may also have a light texturefor comfort and/or exfoliation. In one embodiment, the texture consistsof bumps or dots that form a pattern on the surface of the wipe, and thedots have a height above the surface of the wipe in the range of 0.1 to500 microns, such as from 50 to 100 microns, or from 50 to 80 microns,more specifically from 55 to 75 microns. One embodiment has dots havinga thickness of 70 microns. The texture may result from adding materialto the wipe substrate by printing or spraying a material that is eithersolid or cures after application, or deforming or heating the wipe suchas by passing the wipe through a roller nip, or by calendaring.

If a specific height range for the texture is desired, the surfacetexture of a wipe may be measured using an optical 3D measuring devicealso known as MikroCAD Optical Profilometer by GFM™ (GFMesstechnik GmbH,Germany). The measuring device utilizes a CCD (Charged Coupled Device)camera coupled with a stripe light projector (SLP) where the object tobe measured is angular lighted under a defined angle (45°) with an arrayof equidistant stripes. Thus, height information is included in stripeposition as well as the grey value providing high resolution of surfacegeometries. Image analysis software provided by GFM™ (ODSCAD 5.075 E) isutilized for characterizing texture (heights) on a textured nonwovenmaterial sample. Test samples of a wipe are cut to 18 cm length in theMD and 10 cm length in the wipes' CD. For these samples the MikroCADoptical profilometer from GFMesstechnik GmbH is used to measuringtexture (height) for the samples. The measurement is performed on bothsides of the samples in a relaxed state without any strain and afterabout 25% strain in the CD. All the images are scaled and calibratedbefore measuring the actual heights in micrometers (μm). A dot is markedon each of samples to enable a repeatable positioning of the instrumentfrom side to side.

According to the Handbook of Non-Prescription Drugs (2017), rubbing asolution into an affected area has a higher efficacy than spraying thesolution onto the area. Only by rubbing the solution into the area witha textured wipe will achieve a higher efficacy while exfoliating toremove infected dead skin cells. In the embodiments where the solutionis contained in a cream, lotion or fluid form, the user would bedirected to use a towel, piece of other material, cloth or paper towelto rub the solution into the skin.

The substrate receives the treatment solution to a saturation level thatwill allow the treatment solution to be applied to the user's foot orfeet, while at the same time not being too drippy or messy. “Saturationloading” and “lotion loading” are used interchangeably herein and referto the amount of liquid composition applied to the wipe. In general, theamount of liquid composition applied may be chosen in order to providemaximum benefits to the end product comprised by the wipe. Saturationloading is typically expressed as grams of liquid composition per gramof dry wipe. In one embodiment, the substrate is loaded to range of 300to 400%.

In this manner, an antifungal treatment solution with several otherbeneficial properties is applied to a substrate to a saturation levelthat it will allow the solution to be usefully applied to the surfacesof a user's foot or feet. The solution will treat and prevent suchfungal conditions as athlete's foot, as well as providing healing andsoothing properties. It eliminates odors, and both has a fresh scent andleaves a user's feet smelling fresh.

While the embodiments above refer to the application of the solutionthrough a wipe to the user's feet, the solution may be applied by acream, lotion or other fluid to other parts of the user's skin than thefeet. It can be used to fight many different types of fungal infections,including jock itch, athlete's foot, ringworm, while not being limitedto those examples. This includes the application by an aerosol spray, byinclusion of an aerosol propellant in the solution and putting thesolution in an aerosol container, and includes a pump sprayer, thattypically uses air in a pump spray container. However, as noted above,wiping the feet with the solution provides beneficial effects.

Emnbodiments

One embodiment of the treatment solution disclosed comprises aneffective amount of an antifungal agent, an antifungal agent solvent,and a carrier fluid where the antifungal agent is selected from anaphthyl thiocarbamate, the antifungal agent solvent is selected from aheterocyclic acetyl solvent and the carrier fluid is essentially free ofalcohols. The treatment solution as described above formulated where thecarrier fluid comprises water, glycerol, ethylene glycol, low molecularweight polyethylene glycol and mixtures thereof. An embodiment of thetreatment solution as described above formulated where the carrier fluidcomprises water and glycerol. An embodiment of the treatment solution asdescribed above formulated where the carrier fluid is water. Additionalembodiments of the treatment solution as described above are formulatedwhere the carrier fluid is water an low molecular weight polyethyleneglycol, the low molecular weight polyethylene glycol comprising anaverage weight average molecular weight less than 1500, such as between300 and 1500.

Embodiments of the present treatment solution comprising an effectiveamount of an antifungal agent, an antifungal agent solvent, and acarrier fluid where the carrier fluid is essentially free of alcohol andthe antifungal agent solvent is essentially free of alcohol.

Embodiments of the present treatment solution comprising an effectiveamount of an antifungal agent; an antifungal agent solvent with a logKowbetween about −1 and about 1; or from about −1 to about 0; and water;where the treatment solution is essentially free of alcohol. Embodimentsof the treatment solution as described above wherein the antifungalagent solvent comprises a boiling point below 150° C., or below 100° C.to about 30° C. The treatment solution as described above wherein theratio of the antifungal agent to the antifungal agent solvent is from1:6 to 6:1, such as 1:1, 1:2, 1:3, 1:4, 1:5, 1:.6, 6:1, 5:1, 4:1, 3:1,and 2:1 including any ratio within.

Embodiments of the present treatment solution as described above whereinthe antifungal agent solvent is selected from a heterocyclic acetylsolvent. In one embodiment, the antifungal agent solvent is selectedfrom 1,3-dioxolan, 4-Methyl-1,3-dioxolane, 2-methyl-1,3-dioxolane,(2-Methyl-1,3-dioxolan-4-yOmethanol, 1,3-Dioxepane,1,3-Dioxolane-4-methanol, 5-Hydroxy-1,3-dioxane, Glycrol formal mixture(60:40) of 1,3-Dioxolane-4-methanol:5-Hydroxy-1,3-dioxane, 1,4-dioxane,1,3-dioxolane-2-one, and mixtures thereof.

In one embodiment, the treatment solution as described above where theantifungal agent is selected from tolnaftate, clioquinol, haloprogin,miconazole nitrate, povidone iodine, undecylenic acid and its salts,clotrimazole and mixtures thereof, and terbinafine hydrochloride. Thetreatment solution as described above where the antifungal agent istolnaftate at a concentration of approximately 1%.

Other embodiments may use medications not included in the FDA'smonograph, including ketoconazole, an imidazole,(1-[4-(4-{[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-1-piperazinyl]ethanone);sulconazole, an imidazole(1-{2-[(4-Chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole);sertaconazole, an imidazole(1-{2-[(7-Chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole);betamethasone((11β,16β)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione)+clotrimazole,an imidazole (1-[(2-Chlorophenyl)(diphenyl)methyl]-1H-imidazole);ciclopirox (6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone); econazole(1-{2-[(4-Chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole);naftifin ((2E)-N-Methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine);oxiconazole((1Z)-N-[(2,4-Dichlorobenzyl)oxy]-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanimine);butenafine, a Trimethylamine,(N-Methyl-1-[4-(2-methyl-2-propanyl)phenyl]-N-(1-naphthylmethyl)methanamine);undecylenic acid+cholorozylenol (para-chloro-meta-xylenol).

Embodiments of the treatment solution as described above whichadditionally comprise essential oils. Some embodiments of the treatmentsolution as described above where the essential oils are selected fromchamomile oil, geranium oil, peppermint oil, eucalyptus oil, juniperoil, sandalwood oil, rose oil, lavender oil, and mixtures thereof.

Embodiments of the treatment solution as described above which furthercomprise vitamin E and vitamin E esters, and salts thereof, such astocopheryl acetate and tocopheryl succinate, tocopheryl nicotinate,tocopheryl linolate, alpha-tocopheryl phosphates

Embodiments of the treatment solution as described above which furthercomprise between about 0.01% to about 10% of one or more surfactants.These embodiments may contain one or more surfactants selected fromlauroyl sarcosinate, lauryl amphoacetate, sorbitan laurate, their saltsand mixtures thereof. Other embodiments may comprise the one or moresurfactants selected from sodium lauroyl sarconsiate and sodium laurylamphoacetate; the treatment solution comprises between about 0.01% toabout 10 wt % of the one or more surfactants.

Embodiments of the present treatment solution described above furthercomprise an emollient. Embodiments or these treatment solutionsdescribed where the emollient comprises glycerin, gossypium herbaceum(cotton seed oil), polyglyceryl-4 laurate, dilauryl citrate, ethylhexylstearate, caprylyl glycol and mixtures thereof.

Embodiments of the present treatment solution described above furthercomprise a thickening agent. The embodiments of treatment solutiondescribed above where the thickening agent is selected from ammoniumacryloyldimethyltaurate/Vp copolymer, sodium polyacrylate, a mixture ofcaprylic/capric triglyceride and ammonium acryloyldimethyltaurate/VPcopolymer, xanthan gum, karaya gum, alginates, sclerotium gum,galactoarabinan, diutan gum, guar gum, locust bean gum, and gellan gum;fumed silicas and treated silicas; silicates; starch and its hydrophilicderivatives; and mixtures thereof.

Embodiments of the treatment solution as described above wherein theantifungal agent is not water soluble; the antifungal agent complexeswith the antifungal solvent to form a water-miscible antifungal agentcomplex; the antifungal agent complex is miscible with the carrierfluid.

Embodiments of the present treatment solution comprising an effectiveamount of an antifungal agent, the antifungal agent is solubilized in anantifungal agent solvent, the antifungal agent solvent is miscible inwater; wherein the treatment solution is essentially free of alcohols.

Embodiments of the present treatment solution as described above whereinthe antifungal agent solvent is selected from 1,3-dioxolan,4-Methyl-1,3-dioxolane, 2-methyl-1,3-dioxolane,(2-Methyl-1,3-dioxolan-4-yOmethanol, 1,3-Dioxepane,1,3-Dioxolane-4-methanol, 5-Hydroxy-1,3-dioxane, Glycrol formal mixture(60:40) of 1,3-Dioxolane-4-methanol:5-Hydroxy-1,3-dioxane, 1,4-dioxane,1,3-dioxolane-2-one, and mixtures thereof. Some of the embodimentsdescribed above where the antifungal agent is selected from tolnaftate,clioquinol 3%; haloprogin 1%; miconazole nitrate 2%; povidone iodine10%; undecylenic acid and its salts 10-25%; clotrimazole 1%; terbinafinehydrochloride; and mixtures thereof.

Embodiments of the antifungal and conditioning wipe article comprise asubstrate, and a treatment solution comprising an effective amount of anantifungal agent, an antifungal agent solvent and a carrier fluid.Embodiments of the antifungal and conditioning wipe article as describedabove where the substrate is insoluble in the treatment solution. Someof the embodiments of the wipe article described above where thesubstrate is woven or non-woven sheet comprising wood based fiberscomposed of cellulose precipitated from an organic solution in which nosubstitution of fiber hydroxyl group takes place (lyocell). Otherembodiments of the wipe articles described above where the substratesheet also comprises fibers of the group consisting of silk fiberscotton fibers rayon fibers polyester linen fibers nylon fibers woodfibers and mixtures thereof. Some embodiments of the wipe articlesdescribed above wherein the substrate has a basis weight ranging fromabout 25 g/m² to about 75 g/m². Other embodiments of the wipe articlesdescribed above wherein the substrate has a basis weight ranging fromabout 40 g/m² to about 60 g/m². Wipe articles described above where thesubstrate is textured having a profilometric range of 0.01 microns to500 microns.

A packaged article comprises a plurality of antifungal and conditioningwipes as described above and a container. The package article asdescribed above wherein the container is selected from the groupconsisting of a pop-up container a flat-pack or, tub, a refill package,resealable bag, or a single, individually packaged wipe.

In this manner, an antifungal treatment solution with several otherbeneficial properties is applied to a substrate to a saturation levelthat it will allow the solution to be usefully applied to the surfacesof a user's skin at the tinea infection affected area, such as a foot orfeet. The solution will treat and/or prevent such fungal conditions,such as athlete's foot, as well as providing healing and soothingproperties. It eliminates odors, and both has a fresh scent and leaves auser's feet smelling fresh.

One example of an embodiment of the alcohol free antifungal treatmentsolution is made having the following formulation.

Component Amount (wt %) Glycerine 0.25%-0.50% Dioxolane 1.00%-4.00%Tolnaftate At least 1.00% Sodium Lauroyl Sarcosinate 1.00%-1.50% SodiumLauroamphoacetate 0.75%-1.25% Mentha Piperita Oil (Peppermint Oil)0.075%-0.125% Eucalyptus Gloulus Leaf Oil (Eucalyptus Oil) 0.075%-0.125%Blend: Ethylhexyl Stearate, Sorbitan  0.5%-1.50% Laurate,Phenoxyethanol, Gossypium Herbaceum (Cotton) Seed Oil, Polyglyceryl-4Lautate, Dilauryl Citrate (TEGO Wipe Lux, Evonik) Blend: Phenoxyethanoland Caprylyl Glycol  0.25%-0.075% Tocopheryl Acetate (Vitamin E) 0.005%-0.0125    Ammonium Acryloyldimethyltaurate/VP Copolymer0.05%-1.25% Water q.s. to 100%

EXAMPLE 2

INCI Name Trade Name Supplier % Water DI Water Manufacturer  91.69%Glycerin Glycerin Choice  0.35% Vegetable, USP Dioxolane Dioxolane UltraPur BASF  2.00% Tolnaftate Tolnaftate Choice  1.00% SodiumLauroylSensactive L-30 Chemyunion  1.25% Sarcosinate Sodium Pureact LAAInnospec  1.00% Lauroamphoacetate Mentha Piperita Oil Peppermint OilJedwards  0.10% International, Inc. Eucalyptus Globulus Biochemica ®Hallstar  0.10% Leaf Oil Eucalyptus Oil Ethylhexyl Stearate, TEGO WipeLux Evonik  1.00% Sorbitan Laurate, Phenoxyethanol, Gossypium Herbaceum(Cotton) Seed Oil, Polyglyceryl-4 Laurate, Dilauryl CitratePhenoxyethanol Symocide PC Symrise  0.50% (and) Caprylyl GlycolTocopheryl Acetate Vitamin E Acetate Choice  0.01% Ammonium AristoflexAVC Clariant—  1.00% Acryloyldimethyl- Personal taurate/VP CareCopolymer Total 100.00%

EXAMPLE 3

INCI Name Trade Name Supplier % Water DI Water Manufacturer q.s.Propanediol Zemea Dupont, Tate 5.00% and Lyle Disodium EDTA DisodiumEDTA Choice 0.10% Dioxolane Dioxolane Ultra Pur BASF 3.00% TolnaftateTolnaftate Choice 1.00% Sodium Lauroyl Sensactive L-30 Chemyunion 1.50%Sarcosinate Sodium Pureact LAA Innospec 1.25% Lauroamphoacetate MenthaPiperita Oil Peppermint Oil Jedwards 0.10% International, Inc.Eucalyptus Globulus Biochemica ® Hallstar 0.10% Leaf Oil Eucalyptus OilEthylhexyl Stearate, TEGO Wipe Lux Evonik 1.00% Sorbitan Laurate,Phenoxyethanol, Gossypium Herbaceum (Cotton) Seed Oil, Polyglyceryl-4Laurate, Dilauryl Citrate Phenoxy ethanol (and) Symocide PC Symrise0.50% Caprylyl Glycol Tocopheryl Acetate Vitamin E Acetate Choice 0.01%Ammonium Acryloyldimethyl- Aristoflex AVC Clariant— 1.00% taurate/VPPersonal Copolymer Care Total 100.00% 

Example 4 consists of any of the above examples, with the antifungalagent replaced with terbinafine hydrochloride in the range of 1.0 to 3.0wt %, with adjustments made to at least one of the ranges of thedioxolane or water.

Example 5 consists of any of the above examples, with the antifungalagent replaced with butenafine hydrochloride in the range of 1.0 to 3.0wt %, with adjustments made to at least one of the ranges of thedioxolane or water.

Example 6 consists of any of the above examples, with the antifungalagent replaced with clotrimazole in the range of 1.0 to 3.0 wt % withadjustments made to at least one of the ranges of dioxolane or water.

Example 7 consists of any of the above examples, with the antifungalagent replaced with clioquinol in the range of 1.0 to 3.0 wt % withadjustments made to at least one of the ranges of dioxolane or water.

Example 8 consists of any of the above examples, with the antifungalagent replaced with haloprogin in the range of 1.0 to 3.0 wt % withadjustments made to at least one of the ranges of dioxolane or water.

Example 9 consists of any of the above examples, with the antifungalagent replaced with miconazole nitrate in the range of 1.0 to 3.0 wt %with adjustments made to at least one of the ranges of dioxolane orwater.

Example 10 consists of any of the above examples with the antifungalagent replace with povidone iodine in the range of 1 wt % - 12 wt %,with adjustments made to at least one of the ranges of dioxolane orwater.

Example 11 consists of any of the above examples with the antifungalagents replaced with undecylenic acid in the range of 10 wt % to 25 wt%, with adjustments made to at least one of the ranges of the dioxolaneor water.

Example 12 consists of any of the above examples with the antifungalagents replaced with one of: ketoconazole, an imidazole,(1-[4-(4-{[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-1-piperazinyl]ethanone);sulconazole, an imidazole(1-{2-[(4-Chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole);sertaconazole, an imidazole(1-{2-[(7-Chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole);betamethasone((11β,16β)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione)+clotrimazole,an imidazole (1-[(2-Chlorophenyl)(diphenyl)methyl]-1H-imidazole);ciclopirox (6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone); econazole(1-{2-[(4-Chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole);naftifin ((2E)-N-Methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine);oxiconazole((1Z)-N-[(2,4-Dichlorobenzyl)oxy]-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanimine);butenafine, a Trimethylamine,(N-Methyl-1-[4-(2-methyl-2-propanyl)phenyl]-N-(1-naphthylmethyl)methanamine);undecylenic acid+cholorozylenol (para-chloro-meta-xylenol) in the rangeof 1.0 wt % to 15wt %, with adjustments made to at least one of theranges of the dioxolane or water.

It will be appreciated that variants of the above-disclosed and otherfeatures and functions, or alternatives thereof, may be combined intomany other different systems or applications. Various presentlyunforeseen or unanticipated alternatives, modifications, variations, orimprovements therein may be subsequently made by those skilled in theart which are also intended to be encompassed by below claims.

What is claimed is:
 1. A wipe, comprising: a substrate; and a treatmentsolution impregnated into the substrate, the treatment solutioncomprising: an antifungal agent; an antifungal agent solvent; and acarrier fluid, wherein the treatment solution is essentially free ofalcohol.
 2. The wipe as claimed in claim 1, wherein the antifungal agentcomprises a naphthyl thiocarbamate.
 3. The wipe as claimed in claim 1,wherein the antifungal agent comprises tolnaftate.
 4. The wipe asclaimed in claim 1, wherein the antifungal agent solvent comprises aheterocyclic acetal solvent.
 5. The wipe as claimed in claim 1, whereinthe antifungal agent solvent comprises dioxolane.
 6. The wipe as claimedin claim 1, wherein the substrate comprises at least one selected fromthe group consisting of: creped tissue; un-creped tissue; coformproducts; hydroentangled webs; air-laid mats; fluff pulp; nonwoven webs;woven webs; composites of any of the previous; lyocell; viscose rayon;blends of lyocell; and blends of viscose rayon.
 7. The wipe as claimedin claim 1, wherein the substrate is one of textured or smooth.
 8. Thewipe claimed in claim 1, wherein the substrate has a basis weight in therange of 40 to 60 grams per square meter.
 9. A wipe, comprising: asubstrate; and a treatment solution impregnated into the substrate, thetreatment solution comprising: an antifungal agent; an antifungal agentsolvent; and a carrier fluid, wherein the treatment solution has analcohol content of 6 wt % or below of the total solution..
 10. The wipeas claimed in claim 9, wherein the treatment solution has an alcoholcontent of 5 wt % or below.
 11. The treatment solution as claimed inclaim 9, wherein the treatment solution has an alcohol content of 4 wt %or below.
 12. The treatment solution as claimed in claim 9, wherein thetreatment solution has an alcohol content of 3 wt % or below.
 13. Thetreatment solution as claimed in claim 9, wherein the treatment solutionhas an alcohol content of 2 wt % or below.
 14. The wipe as claimed inclaim 9, wherein the antifungal agent comprises a naphthylthiocarbamate.
 15. The wipe as claimed in claim 9, wherein theantifungal agent comprises tolnaftate.
 16. The wipe as claimed in claim9, wherein the antifungal agent solvent comprises a heterocyclic acetalsolvent.
 17. The wipe as claimed in claim 9, wherein the antifungalagent solvent comprises dioxolane.
 18. The wipe as claimed in claim 9,wherein the substrate comprises at least one selected from the groupconsisting of: creped tissue; un-creped tissue; coform products;hydroentangled webs; air-laid mats; fluff pulp; nonwoven webs; wovenwebs; composites of any of the previous; lyocell; viscose rayon; blendsof lyocell; and blends of viscose rayon.
 19. The wipe claimed in claim9, wherein the substrate has a basis weight in the range of 40 to 60grams per square meter.
 20. A treatment solution, comprising: asubstrate; and a treatment solution impregnated into the substrate, thetreatment solution comprising: an antifungal agent comprising a naphthylthiocarbamate; a carrier fluid; and an antifungal agent solventcomprising a dioxolane solvent miscible with the carrier and having alogKow with a range of −1 to 1, the dioxolane comprising one selectedfrom the group selected from: 1,3-dioxolane, 4-Methyl-1,3-dioxolane,2-methyl-1,3-dioxolane, (2-Methyl-1,3-dioxolane-4-yl) methanol,1,3-Dioxepane, 1,3-Dioxolane-4-methanol, 5-Hydroxy-1,3-dioxane, Glycrolformal mixture (60:40) of1,3-Dioxolane-4-methano1:5-Hydroxy-1,3-dioxane, 1,4-dioxane,1,3-dioxolane-2-one, and mixtures thereof.